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Search Results for " serine hydrolase "

Targets Recommended: FAAH Autophagy

15

抑制剂 & 化合物

6

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T15802	LY2183240	FAAH; Autophagy	Autophagy; Metabolism; Neuroscience
	LY2183240 是大麻素摄取阻滞剂。它是内源性大麻素降解酶脂肪酸酰胺水解酶的有效共价抑制剂。它抑制脂肪酸酰胺水解酶 (FAAH) 活性，IC50 为12.4 nM。它也抑制其他几种脑丝氨酸水解酶，对 MAG 脂肪酶、bh6 和 KIAA1363 的 IC50分别为 5.3、0.09 和 8.2 nM。
T9374	AA38-3 1-Piperidinecarboxylic acid, 4-nitrophenyl ester	FAAH; Lipase; MAGL	Metabolism; Neuroscience
	AA38-3 (1-Piperidinecarboxylic acid, 4-nitrophenyl ester) 是丝氨酸水解酶抑制剂，能够抑制三种 SHs：ABHD6，ABHD11 和 FAAH。
T78174	Serine Hydrolase inhibitor-21	Others	Others
	Serine Hydrolase inhibitor-21（化合物8）为一种抑制丝氨酸水解酶的吡啶类化合物，其对BuChE的Ki值为429 nM，有望用于阿尔茨海默病的研究。
T8927	WWL 154 WWL-154	FAAH	Metabolism; Neuroscience
	WWL 154 是一种丝氨酸水解酶 (SH) 和脂肪酸酰胺水解酶 FAAH-4 抑制剂。
T22883	JW 480	Others	Others
	JW 480 是一种有效的丝氨酸水解酶 KIAA1363选择性抑制剂。
T23602	ABC99 ABC 99,ABC-99	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	ABC99是 wnt 脱酰基酶的一种选择性不可逆抑制剂。ABC99抑制 NOTUM（IC50:13 nM）。它还显示了对丝氨酸水解酶家族的优良选择性。
T9733	PAL-4 1H-1,2,4-Triazol-5-amine, 3-[[(4-chlorophenyl)methyl]thio]-1-[(2,3-dihydro-5-benzofuranyl)sulfonyl]-	Others	Others
	PAL-4刺激 LYPLAL1 的活性, 一种特征不佳的丝氨酸水解酶，与人类代谢特征具有复杂的遗传联系。
T3990	AA26-9	Phospholipase; Serine Protease	Metabolism; Proteases/Proteasome
	AA26-9 是广谱丝氨酸水解酶的高效抑制剂。它的靶点包括丝氨酸肽酶、酰胺酶、脂肪酶、酯酶和硫酯酶。在永生化 T 细胞系，检测到它对 40+ 丝氨酸水解酶中的 1/3 有抑制作用。
T17259	WWL113	Others	Others
	WWL113 is a selective and orally active Ces3 and Ces1f inhibitor (IC50: 120 nM and 100 nM for Ces3 and Ces1f, respectively). WWL113 appears to display excellent selectivity for the 60-kDa serine hydrolase.
T38316	ABC34
	ABC34 is an inactive control probe for JJH260 , the inhibitor of androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). ABC34 demonstrates an IC50 value greater than 25 μM for the inhibition of 9-PAHSA but is more potent in blocking the serine hydrolase ABHD6 and the palmitoyl-protein hydrolase PPT1, which are both off-targets of JJH260.
T64082	ABC44
	ABC44 是丝氨酸水解酶 (serine hydrolase) 的有效抑制剂，对棕榈酰蛋白硫酯酶 1 (PPT1) 原位和体外的 IC50 分别为 0.1 μM 和 6.5 μM。ABC44 能够用于研究婴儿晚期神经元样脂褐质沉积症。
T38107	JJH260 JJH260
	JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). It blocks the hydrolysis of 9-PAHSA with an IC50 value of 0.57 μM. JJH260 also inhibits the novel FAHFA hydrolase androgen-dependent TFPI-regulating protein (ADTRP; IC50 = 8.5 μM), as well as the serine hydrolase ABHD6 and the lysophospholipases LYPLA1 and LYPLA2. JJH260 inhibits the FAHFA hydrolase activity of LNCaP and T cell lysa...
T36338	AAF-CMK (trifluoroacetate salt)
	Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides. AAF-CMK is an irreversible inhibitor of TPPII commonly used at 10-100 μM. It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at 50 μM.
T73317	JZP-MA-13
	JZP-MA-13是一种选择性α/β-水解酶结构域6 (ABHD6) 抑制剂，其IC50值为392 nM。该化合物对MAGL、ABHD12、FAAH或其它丝氨酸水解酶不表现出抑制作用。JZP-MA-13还被用作ABHD6在体内成像的正电子发射断层扫描(PET)配体。
T36055	Nitisinone-13C6 Nitisinone-13C6
	Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyruvate (HPPA) to homogentisate in the tyrosine catabolic pathway.1Nitisinone increases urinary levels of HPPA and 4-hydroxyphenyllactate (HPLA) in rats when administered at a dose of 10 mg/kg. Nitisinone (3 mg/kg) prevents the neonatal lethality of fumarylacetoacetate hydrolase (F...

化合物

Cat.No: T15802

Target: FAAH, Autophagy

Cat.No: T9374

Synonym: 1-Piperidinecarboxylic acid, 4-nitrophenyl ester

Target: FAAH, Lipase, MAGL

Serine Hydrolase inhibitor-21

Cat.No: T78174

Target: Others

Cat.No: T8927

Synonym: WWL-154

Target: FAAH

Cat.No: T22883

Target: Others

Cat.No: T23602

Synonym: ABC 99,ABC-99

Target: Wnt/beta-catenin

Cat.No: T9733

Synonym: 1H-1,2,4-Triazol-5-amine, 3-[[(4-chlorophenyl)methyl]thio]-1-[(2,3-dihydro-5-benzofuranyl)sulfonyl]-

Target: Others

Cat.No: T3990

Target: Phospholipase, Serine Protease

Cat.No: T17259

Target: Others

Cat.No: T38316

Cat.No: T64082

Cat.No: T38107

Synonym: JJH260

AAF-CMK (trifluoroacetate salt)

Cat.No: T36338

Cat.No: T73317

Nitisinone-13C6

Cat.No: T36055

Synonym: Nitisinone-13C6

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03330	BPHL Protein, Human, Recombinant (His) biphenyl hydrolase-like (serine hydrol...	Human	E. coli
	BPHL is a member of the serine protease family. BPHL is expressed large quantities in liver and kidney and in minor quantities in heart, intestine and skeletal muscle. BPHL is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. It catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir ...
TMPJ-00459	Esterase D Protein, Human, Recombinant (His) FGH,Methylumbelliferyl-Acetate Deacetylase,ESD,S-Formylgluta...	Human	E. coli
	Human Esterase D is a cytoplasmic serine hydrolase that belongs to the esterase D family. Esterase D is involved in the detoxification of formaldehyde. Esterase D plays a part in a variety of substrates, including O-acetylated sialic acids, which may involves in the recycling of sialic acids. Esterase D is used as a genetic marker for retinoblastoma and Wilson’s disease.
TMPJ-00881	CTRB1 Protein, Human, Recombinant (His) CTRB,CTRB1,Chymotrypsinogen B	Human	HEK293 Cells
	Chymotrypsinogen B (CTRB1) is a 263 amino acid protein with signal peptide (1-18) and Chymotrypsinogen B (19-263). Chymotrypsinogen B have three chains:Chymotrypsin B chain A(19-31), Chymotrypsin B chain B(34-164), Chymotrypsin B chain C (167-263). Chymotrypsinogen B is a Serine Protease Hydrolase secrets into gastrointestinal tract as the inactive precursor Chymotrypsinogen.
TMPH-02866	RBBP9 Protein, Mouse, Recombinant (His)	Mouse	P. pastoris (Yeast)
	Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1. RBBP9 Protein, Mouse, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 22.4 kDa and t...
TMPY-03391	ESD Protein, Human, Recombinant (His) esterase D,FGH	Human	E. coli
	Esterase D, also known as ESD, is a serine hydrolase that belongs to the esterase D family. Esterase D is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids. Esterase D gene is used as a genetic marker and a diagnostic tool for retinoblastoma, Wilson's disease and other hereditary or acquired diseases controlled by genes located at the 13 chromosome 13q14 region.
TMPJ-01440	Cutinase Protein, Thermobifida fusca, Recombinant (His) Cutinase	Thermobifida fusca	E. coli
	Cutinase belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is cutin hydrolase. Cutinase is a serine esterase containing the classical Ser, His, Asp triad of serine hydrolases. The protein belongs to the alpha-beta class, with a central beta-sheet of 5 parallel strands covered by 5 helices on either side of the sheet. Cutin monomers released from the cuticle by small amounts of cutinase on fungal spore surfaces can g...

重组蛋白

BPHL Protein, Human, Recombinant (His)

Cat.No: TMPY-03330

Species: Human

Expression System: E. coli

Esterase D Protein, Human, Recombinant (His)

Cat.No: TMPJ-00459

Species: Human

Expression System: E. coli

CTRB1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00881

Species: Human

Expression System: HEK293 Cells

RBBP9 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02866

Species: Mouse

Expression System: P. pastoris (Yeast)

ESD Protein, Human, Recombinant (His)

Cat.No: TMPY-03391

Species: Human

Expression System: E. coli

Cutinase Protein, Thermobifida fusca, Recombinant (His)

Cat.No: TMPJ-01440

Species: Thermobifida fusca

Expression System: E. coli

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